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stoA [2017-8-11 16:0:3]
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stoA [2017-8-11 16:0:3]

thiol-disulfide oxidoreductase, with thioredoxin-like domain, required for the synthesis of the endospore peptidoglycan cortex
locus
BSU13840
pI
5.30
mw
18.66 kDa
protein length
165 aa Sequence Blast
gene length
495 bp Sequence Blast
function
spore cortex formation, maturation of [protein|search|SpoVD ]in the forespore outer membrane
product
thiol-disulfide oxidoreductase
essential
no
synonyms
spoIVH,ykvV

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,450,638 → 1,451,135

    The protein

    Catalyzed reaction/ biological activity

  • reduction of intramolecular disulfide bonds in [protein|38FD9805815BBDDD83789F0F402C0FB221B65FF4|SpoVD] in the forespore outer membrane [Pubmed|19919673]
  • Protein family

  • thioredoxin domain (according to Swiss-Prot)
  • Structure

  • [PDB|3ERW]
  • [SW|Localization]

  • forespore envelope [Pubmed|19919673]
  • Expression and Regulation

    Operons

    genes
    [gene|34A5CD28A3DBCB10B4E1C82E50143FA73B553919|ykvU]-[gene|0B299F9459023306FA91298A6162A09E4A87C3B2|stoA]
    description
    [Pubmed|15292147]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|12662922], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
  • [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG]: sigma factor, [Pubmed|15292147], in [regulon|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG regulon]
  • regulation

  • expressed during sporulation ([protein|search|SigE], [protein|search|SigG]) [Pubmed|12662922,15292147]
  • additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|stoA]' and '[protein|search|zosA]' [PubMed|20525796]
  • view in new tab

    genes
    [gene|0B299F9459023306FA91298A6162A09E4A87C3B2|stoA]
    description
    [Pubmed|15292147]

    regulation

  • expressed during sporulation ([protein|search|SigE], [protein|search|SigG]) [Pubmed|12662922,15292147]
  • additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|stoA]' and '[protein|search|zosA]' [PubMed|20525796]
  • view in new tab

    Biological materials

    Mutant

  • MGNA-B328 (ykvV::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1327 NBRP B. subtilis, Japan]
  • 1S130 ( ''stoA''::''cat''), [Pubmed|15342593], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S130&Search=1S130 BGSC]
  • 1S131 ( ''stoA''::''tet''), [Pubmed|15342593], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S131&Search=1S131 BGSC]
  • Labs working on this gene/protein

  • [SW|Lars Hederstedt], University of Lund, Sweden [http://www.cob.lu.se/microbiology/heme.html Homepage]
  • References

    Reviews

  • 19919674
  • Original Publications

  • 12662922,15292147,15342593,19144642,19919673,20525796,28383125